Regional Genetics Service

Address

Yorkshire Regional Molecular Genetics Laboratory,

Ashley Wing,

St James’s Hospital,

Beckett Street,

Leeds

LS9 7TF

Contact 1

 Dr Ruth S Charlton

Contact 2

 Dr David J Cockburn

Contact 3

 Duty Scientist

Telephone 1

 +44 (0)113 206 6918

Telephone 2

 +44 (0)113 206 4642

Telephone 3

 +44 (0)791 7076659

Fax:

 +44 (0)113 246 7090

Email 1

 Ruth.Charlton@leedsth.nhs.uk

Email 2

 David.Cockburn@leedsth.nhs.uk

Home page

http://www.leedsth.nhs.uk/sites/leedsdna

UKGTN Website

http://www.ukgtn.nhs.uk/gtn/Search/Search_by_Region

 

 

Services offered: 06/10/11 update

Disease

OMIM

UKGTN service*

ADENOMATOUS POLYPOSIS OF THE COLON; APC

 

175100

YES

ADRENAL HYPERPLASIA, CONGENITAL, DUE TO 21-HYDROXYLASE DEFICIENCY

 

201910

YES

AICARDI-GOUTIERES SYNDROME; AGS1, AGS2, AGS3, AGS4, AGS5

225750 (606609)

610181 (610326)

610329 (610330)

610333 (606034)

610905 (606609)

YES

ALSTROM SYNDROME; ALMS

 

203800

606844

YES

BREAST CANCER; BRCA1 & BRCA2

114480

113705

600185

YES

CENTRAL CORE DISEASE OF MUSCLE; CCD; RYR1

 

117000

180901

 

COLORECTAL ADENOMATOUS POLYPOSIS, AUTOSOMAL RECESSIVE; MUTY HOMOLOG (E. COLI); MUTYH

 

608456

604933

YES

COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS; HNPCC; LYNCH SYNDROME; MLH1; MSH2; MSH6

(PMS2 - see separate entry)

 

114500

158320

120436

120435

600678

609309

YES

CYSTIC FIBROSIS; CF; CRTR

219700

602421

YES

FAMILIAL EXUDATIVE VITREORETINOPATHY; FEVR: FZD4; LRP5; NDP
 

133780

305390

601813

604579

603506

300658

YES

GAP JUNCTION PROTEINS, BETA-2 AND BETA-6 ; GJB2 AND GJB6; DEAFNESS, CONNEXIN 26 AND CONNEXIN 30-RELATED

 

121011

604418

220290

612645

YES

GENETIC IDENTITY

 

-

YES

GLUT1 DEFFICIENCY SYNDROME; SLC2A1

138140

606777

 

 

GONADAL DYSGENESIS, XY FEMALE TYPE; GDXY; SRY GENE SEQUENCING

 

306100

480000

 

HARLEQUIN ICTHYOSIS; ABCA12

242500

607800

 

 

HYPERTROPHIC CARDIOMYOPATHY; HCM:

MYBPC3, MYH7, TNNT2, TNNI3

115197

192600

115195

613690

600958

160760

191045

191044

 

HUNTINGTON DISEASE; HD

 

143100

YES

ICHTHYOSIS, X-LINKED; STS DEFICIENCY

 

308100

YES

LI-FRAUMENI SYNDROME; LFS; TP53

 

151623

191170

YES

MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 1; MHS1; RYR1

 

145600

180901

YES

MARFAN SYNDROME; MFS; FBN1

134797

190182

 

 

MECKEL SYNDROME TYPES 1 AND 3; MKS1 & MKS3

249000

609883

607361

609884

YES

MELANOMA, CUTANEOUS MALIGNANT; CMM; CDKN2A; TP16

 

155600

600160

YES

MISMATCH REPAIR CANCER SYNDROME (TURCOT SYNDROME), PMS2 ASSOCIATED

 

276300

600259

Please contact laboratory

MULTIPLE ENDOCRINE NEOPLASIA, TYPE I ; MEN1

 

131100

118930

YES

MULTIPLE ENDOCRINE NEOPLASIA, TYPE II; MEN2A; TYPE IIB; MEN2B; RET:

See PHEOCHROMOCYTOMA

 

See below

 

OCULOPHARYNGEAL MUSCULAR DYSTROPHY; OPMD; PABPN1

164300

602279

YES

OPTIC ATROPHY 1; OPA1; KJER-TYPE

165500

605290

 

PHEOCHROMOCYTOMA:

VHL, SDHB, SDHC, SDHD, SDHAF2, PRKAR1A, RET and TMEM127

 

171300

608537

185470

602413

602690

613019

188830

613403

164761

YES

POLYCYSTIC KIDNEY DISEASE, AUTOSOMAL RECESSIVE; ARPKD; PKHD1

263200

606702

YES

PRIMARY HYPERTROPHIC OSTEOARTHROPATHY; PHO; HPGD; DIGITAL CLUBBING

259100

601688

 

SANDHOFF DISEASE; HEXB

268800

606873

 

SEX DETERMINATION; AMELOGENIN; SRY

300391

410000

480000

YES

TORSION DYSTONIA 1, AUTOSOMAL DOMINANT; DYT1; TOR1A

 

128100

605204

YES

VON HIPPEL-LINDAU SYNDROME; VHL:

See PHEOCHROMOCYTOMA

 

See above  

Y CHROMOSOME MICRODELETIONS

 

-

YES

 

*Services offered outside main commissioning area geographical

boundaries under the UK specialist Genetic Testing Network - enquire to the laboratory on costs.